475880

ML-7, Hydrochloride

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM).

• 동의어(들): ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
• 실험식(Hill 표기법): C₁₅H₁₇IN₂O₂S · xHCl
• CAS Number: 110448-33-4
• Molecular Weight: 416.28 (free base basis)
• MDL number: MFCD00065524
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >98% (TLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: 50% ethanol: 4.5 mg/mL; DMSO: 4.5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
• InChI key: GEHJIACZUFWBTK-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM). Inhibits protein kinase A (K_i = 21 µM) and protein kinase C (K_i = 42 µM) at much higher concentrations.

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM). Inhibits protein kinase A (K_i = 21 µM)and protein kinase C (K_i = 42 µM) at much higher concentrations.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Myosin light chain kinase (Mlck)

Product competes with ATP.

Reversible: yes

Target K_i: 300 nM against myosin light chain kinase

경고

Toxicity: Standard Handling (A)

제조 메모

Further dilute with aqueous buffer just prior to use.

재구성

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

기타 정보

Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable