444151
Nutlin-3
InSolution, ≥98%, Racemic, potent and selective MDM2 antagonist
동의어(들):
InSolution Nutlin-3, Racemic, MDM2 Inhibitor IV
로그인조직 및 계약 가격 보기
크기 선택
1 MG
₩196,403
₩196,403
예상 입고일2025년 5월 07일세부사항
모든 사진(1)
크기 선택
보기 변경
1 MG
₩196,403
About This Item
실험식(Hill 표기법):
C30H30Cl2N4O4
Molecular Weight:
581.49
UNSPSC 코드:
12352200
NACRES:
NA.77
₩196,403
예상 입고일2025년 5월 07일세부사항
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
liquid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
protect from light
배송 상태
wet ice
저장 온도
−20°C
일반 설명
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
포장
Packaged under inert gas
경고
Toxicity: Irritant (B)
물리적 형태
A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
재구성
Following initial thaw, aliquot and freeze (-20°C).
기타 정보
Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.
Vassilev, L.T., et al. 2004. Science303, 844.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Flash Point (°C)
87 °C - closed cup - (Dimethylsulfoxide)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Christophe Le Clorennec et al.
International journal of molecular sciences, 24(18) (2023-09-28)
Neuroblastoma (NB) is a pediatric malignancy originating from neural crest cells of the sympathetic nervous system that accounts for 15% of all pediatric cancer deaths. Despite advances in treatment, high-risk NB remains difficult to cure, highlighting the need for novel
B Lamprecht et al.
The British journal of dermatology, 167(2), 240-246 (2012-03-06)
Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group with Sézary syndrome (SS) as one of the most aggressive variants. Recently, we identified a loss of E2A as a recurrent event in SS, which enhanced proliferation via upregulation of the
Anthony M Pettinato et al.
Cell reports, 35(5), 109088-109088 (2021-05-06)
Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using fluorescently tagged cyclin B1 and cardiac troponin T.
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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