233501-M

Coagulation Factor XIII, Human Plasma

Coagulation Factor XIII, Human Plasma, CAS 9013-56-3, is a native tetrameric form composed of two identical α- and two β-subunits. Thrombin converts the α2β2 tetramer to a modified α2ʹβ2 tetramer.

• 동의어(들): Coagulation Factor XIII, Human Plasma, Fibrin-stabilizing Factor
• CAS Number: 9013-56-3
• MDL number: MFCD00005925
• UNSPSC 코드: 12352202

속성

• Quality Level: 100
• 설명: Merck USA index - 14, 3926
• 분석: ≥95% (SDS-PAGE)
• 양식: liquid
• 특이 활성도: ≥40 units/mg protein (clotting assay)
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 저장 온도: −20°C

설명

일반 설명

Native coagulation factor XIII from human plasma. Plasma Factor XIII is a tetramer (α₂β₂) composed of two identical α-subunits and two identical β-subunits. After thrombin cleavage converts the α₂β₂ tetramer to a modified α₂′β₂ tetramer, Ca²⁺ promotes both the dissociation of the β₂ dimer and the activation of the α₂′ dimer to its catalytically active form. This activated Factor XIII (Factor XIIIa) strengthens the fibrin clot by catalyzing the formation of glutamyl-lysine bonds between fibrin monomers.

경고

Toxicity: Standard Handling (A)

단위 정의

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma. One unit is defined as the activity in 1 ml of normal, pooled plasma.

물리적 형태

In 500 µM EDTA, 50% glycerol.

제조 메모

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

재구성

Following initial thaw, aliquot and freeze (-20°C).

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2