23-057-M

Smac/DIABLO

• 동의어(들): Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase (Smac)
• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100
• 형태: liquid
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable
• NCBI 수납 번호: NM_019887

설명

일반 설명

Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c and other pro-apoptotic factors. Once in the cytosol, Smac/DIABLO binds to inhibitors of apoptosis (IAP) proteins and disrupts the ability of the IAPs to inhibit caspases 3, 7, and 9 thereby promoting apoptosis. Along with several other pro-apoptotic proteins, Smac/DIABLO has been shown to be a substrate for the ubiquitin ligase XIAP.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable