217720

Cdk1/5 Inhibitor

The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Cdk1/5 Inhibitor, 3-Amino-1H-pyrazolo[3,4-b]quinoxaline
• 실험식(Hill 표기법): C₉H₇N₅
• CAS Number: 40254-90-8
• Molecular Weight: 185.19
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: red
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)
• InChI key: DWHVZCLBMTZRQM-UHFFFAOYSA-N

설명

일반 설명

A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC₅₀ = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC₅₀ = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC₅₀ >10 µM).

A selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC₅₀ = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC₅₀ = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC₅₀ >10 µM).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Cdk1/cyclin B, Cdk5/p25

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Ortega, M.A., et al. 2002. Bioorg. Med. Chem.10, 2177.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1