203401

Bleomycin Sulfate, Streptomyces verticillus

Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission.

• 동의어(들): Bleomycin Sulfate, Streptomyces verticillus
• CAS Number: 9041-93-4
• MDL number: MFCD00070310
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥90% (A₂ + B₂, HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white to off-white
• solubility: water: 20 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1
• InChI key: WUIABRMSWOKTOF-OCBSMOPSSA-N

설명

일반 설명

A mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.

Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.

생화학적/생리학적 작용

Potency: 1.5-2.0 U/mg

경고

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

재구성

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

기타 정보

Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
Ikeda, S., et al. 1991. Anal. Biochem.192, 96.
Hait, W.N., et al. 1990. Cancer Res.50, 6636.
Arkin, H., et al. 1989. Cancer Res.49, 6556.
Wu, J.C., et al. 1983. J. Biol. Chem.258, 4694.
Takita, T., et al. 1968. Antibiotics21, 79.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H340,H351,H361fd
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Muta. 1B - Repr. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable