203303

Bisindolylmaleimide V

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM).

• 동의어(들): Bisindolylmaleimide V, 2,3- bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045, 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045
• 실험식(Hill 표기법): C₂₁H₁₅N₃O₂
• CAS Number: 113963-68-1
• Molecular Weight: 341.36
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: red-orange
• solubility: DMSO: 10 mg/mL; methanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3
• InChI key: SWAWYMIKGOHZMR-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70^s6k/p85^s6kin vivo (IC₅₀ 8 µM).

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of p70^s6k/p85^s6kin vivo (IC₅₀ = 8 µM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Negative control compound for protein kinase C inhibition

Product does not compete with ATP.

Reversible: no

Target IC₅₀: >100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo

경고

Toxicity: Standard Handling (A)

기타 정보

Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable