추천 제품
Quality Level
분석
≥95% (HPLC)
형태
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
desiccated (hygroscopic)
protect from light
색상
off-white
solubility
DMSO: 10 mg/mL
배송 상태
ambient
저장 온도
2-8°C
일반 설명
A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.
A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
Bax-channel forming activity
Bax-channel forming activity
Product does not compete with ATP.
Reversible: no
Target IC50: 520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
포장
Packaged under inert gas
경고
Toxicity: Carcinogenic / Teratogenic (D)
물리적 형태
Supplied as a trifluoroacetate salt.
재구성
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Peixoto, P., et al. 2009. Biochem J.423, 381.
Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.
Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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