196418

BAPTA, Tetrasodium Salt

Ca2+ chelator exhibiting a 105-fold greater affinity for Ca2+ .

• 동의어(들): BAPTA, Tetrasodium Salt, 1,2- bis( o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na, 1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na
• 실험식(Hill 표기법): C₂₂H₂₀N₂O₁₀ · 4Na
• CAS Number: 126824-24-6
• Molecular Weight: 564.36
• MDL number: MFCD00067691
• UNSPSC 코드: 12352106
• NACRES: NA.25

속성

• Quality Level: 100
• 양식: solid
• 반응 적합성: reagent type: chelator
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: off-white
• solubility: water: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: [Na+].[Na+].[Na+].[Na+].N(CC(=O)[O-])(CC(=O)[O-])c1c(cccc1)OCCOc2c(cccc2)N(CC(=O)[O-])CC(=O)[O-]
• InChI: 1S/C22H24N2O10.4Na/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32;;;;/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32);;;;/q;4*+1/p-4
• InChI key: ZWSMLJACYSGFKD-UHFFFAOYSA-J

설명

일반 설명

Ca²⁺-chelator exhibiting a 10⁵-fold greater affinity for Ca²⁺ (110 nM) than for Mg²⁺. After BAPTA complexes with Ca²⁺, the UV spectrum shifts from 254 to 279 nm at pH >6.0. Useful for spectrophotometric monitoring of extracellular Ca²⁺ levels, especially transient phenomena, because of its insensitivity to pH. Has been used for the measurement and control of Ca²⁺ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg²⁺. Has neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy.

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). To increase stability in solution, store at a high pH (>10). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Li, L., et al. 1995. J. Cell Physiol. 163, 105.
Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable