14-439-M
MAP Kinase 1/Erk1 Protein, active, 10 µg
Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.
동의어(들):
ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK
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모든 사진(2)
About This Item
UNSPSC 코드:
12352202
eCl@ss:
32160405
NACRES:
NA.32
가격 및 재고 정보를 현재 이용할 수 없음
추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
양식
liquid
분자량
Mw 69.9 kDa
제조업체/상표
Upstate®
기술
activity assay: suitable (kinase)
색상
colorless
solubility
water: soluble
NCBI 수납 번호
UniProt 수납 번호
유전자 정보
human ... MAPK3(5595)
일반 설명
Research area: Cell Signaling
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
생화학적/생리학적 작용
Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control.[1] Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle.[2] MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.[3]
포장
Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.
품질
routinely evaluated by phosphorylation of MBP
물리적 형태
Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose
기타 정보
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
법적 정보
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
