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Merck
모든 사진(1)

주요 문서

870865P

Avanti

BMP22

Avanti Research - A Croda Brand, powder

동의어(들):

4-pentadecylbenzylphosphonic acid

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About This Item

실험식(Hill 표기법):
C22H39O3P
CAS Number:
Molecular Weight:
382.52
MDL number:
UNSPSC 코드:
12352211
NACRES:
NA.25

분석

99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (870865P-1mg)
pkg of 1 × 5 mg (870865P-5mg)

제조업체/상표

Avanti Research - A Croda Brand

지질 유형

bioactive lipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1

InChI key

XWVBRTAQHMKHCE-UHFFFAOYSA-N

일반 설명

BMP (bis(monoacylglycerol)phosphate) is synthesized from phosphatidylglycerol (PG) in alveolar macrophages. BMP is a unique phospholipid having a glycerol phosphate ester at sn-1 position rather than sn-3 and has one acyl group attached to each of the glycerol moieties. The acyl groups of BMP is rich in polyunsaturated species.

생화학적/생리학적 작용

BMP (bis(monoacylglycerol)phosphate) (BMP) is found in the retinal pigment epithelium of healthy human retina. BMP lipids regulates cholesterol level in endosomes. It is implicated in endosomal/lysosomal storage diseases like Niemann-Pick and neuronal ceroid lipofuscinosis diseases. BMP22/4PBPA is a small molecule inhibitor of autotaxin (ATX). 4PBPA has relatively a longer half-life and also reduces the lysophosphatidic acid concentration in plasma. BMP22 is implicated in reducing the bone erosion and systemic bone loss.

포장

5ML Glass Amber Screw Cap Vial (870865P-1MG)
5ML Glass Amber Screw Cap Vial (870865P-5MG)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Osteoclast-derived Autotaxin, a distinguishing factor for inflammatory bone loss
Flammier S, et al.
Arthritis and Rheumatism (2019)
Bis (monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas
Anderson DMG, et al.
Scientific Reports, 7(1), 17352-17352 (2017)
Transacylase formation of bis (monoacylglycerol) phosphate
Heravi J and Waite M
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1437(3), 277-286 (1999)
Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
Gotoh M, et al.
Biochemical Society Transactions, 40(1), 31-36 (2012)

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