860654P

sphinganine (d17:0)

Avanti Research^™ - A Croda Brand 860654P, powder

• 동의어(들): D-erythro-sphinganine (C17 base)
• 실험식(Hill 표기법): C₁₇H₃₇NO₂
• CAS Number: 32164-02-6
• Molecular Weight: 287.48
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 형태: powder
• 포장: pkg of 1 × 10 mg (860654P-10mg); pkg of 1 × 5 mg (860654P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 860654P
• 지질 유형: sphingolipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCC
• InChI: 1S/C17H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(20)16(18)15-19/h16-17,19-20H,2-15,18H2,1H3/t16-,17+/m0/s1
• InChI key: KFQUQCFJDMSIJF-DLBZAZTESA-N

설명

일반 설명

Sphinganine (d17:0), also referred to as dihydrosphingosine, is devoid of double bond. Decarboxylating condensation of serine with palmitoyl-CoA yield keto intermediate(2-oxosphinganine), which is then reduced by NADPH to form Sphinganine.

애플리케이션

Sphinganine (d17:0) has been used in liquid chromatography-mass spectrometry (LC-MS) for the in-situ estimation of dihydrosphingosine utilization in N-(4-hydroxyphenyl)retinamide (4-HPR) resistant leukemia cells. It is suitable for use as an internal standard in metabolomic study.

생화학적/생리학적 작용

Sphinganine (SPA) or D-erythro-sphinganine is involved in sphingolipid biosynthesis pathway. It acts as a precursor for ceramide. SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.

포장

5 mL Amber Glass Screw Cap Vial (860654P-10mg)

5 mL Amber Glass Screw Cap Vial (860654P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3