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주요 문서

810211P

Avanti

C12-NBD Ceramide

Avanti Research™ - A Croda Brand 810211P, powder

동의어(들):

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine

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크기 선택

1 MG
₩771,400

₩771,400

출고 가능일2025년 4월 18일세부사항

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모든 사진(1)

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보기 변경
1 MG
₩771,400

About This Item

실험식(Hill 표기법):
C36H61N5O6
CAS Number:
202850-01-9
Molecular Weight:
659.90
MDL number:
MFCD02259239
UNSPSC 코드:
12352211
NACRES:
NA.25

₩771,400

출고 가능일2025년 4월 18일세부사항

벌크 견적 요청

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (810211P-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand 810211P

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[N+](=O)([O-])c1c2n[o]nc2c(cc1)NCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO

InChI

1S/C36H61N5O6/c1-2-3-4-5-6-7-8-9-10-12-15-18-21-24-33(43)31(29-42)38-34(44)25-22-19-16-13-11-14-17-20-23-28-37-30-26-27-32(41(45)46)36-35(30)39-47-40-36/h21,24,26-27,31,33,37,42-43H,2-20,22-23,25,28-29H2,1H3,(H,38,44)/b24-21+/t31-,33+/m0/s1

InChI key

SNOJCYCOPNIGIK-ULETYAGTSA-N

일반 설명

C12 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) ceramide is a long-chain fluorescent phospholipid.[1] It is a natural analog of ceramide with C12 acyl chain length.[2]

애플리케이션

C12-NBD Ceramide or N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine has been used as a substrate in ceramidase activity assay.[3] It is also suitable for the lipid binding assays[4] and in cell culture experiments for endothelial cells to determine the pro-apoptotic intracellular ceramide generation.[5]

생화학적/생리학적 작용

C12-7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) Ceramide is useful for measuring the alkaline and neutral ceramidase activity.[1] It is involved in maintainingthe physical properties of ceramide required for cellular studies.[2]

포장

5 mL Amber Glass Screw Cap Vial (810211P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

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문서 라이브러리 방문

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites
Nikit K, et al.
The Journal of Cell Biology, 217(10), 3625-3639 (2018)
Apoptotic Sphingolipid Signaling by Ceramides in Lung Endothelial Cells
Medler TR, et al.
American Journal of Respiratory Cell and Molecular Biology, 38(6), 639-646 (2008)
M Tani et al.
Journal of biochemistry, 125(4), 746-749 (1999-04-02)
A fluorescent analogue of ceramide, C12-NBD-ceramide, was found to be hydrolyzed much faster than 14C-labeled ceramide by alkaline ceramidase from Pseudomonas aeruginosa and neutral ceramidase from mouse liver, while this substrate was relatively resistant to acid ceramidase from plasma of
Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts)
Meghan PS, et al.
Biochimica et Biophysica Acta, 1768(9), 2205-2212 (2007)
Terry R Medler et al.
American journal of respiratory cell and molecular biology, 38(6), 639-646 (2008-01-15)
The de novo pathway of ceramide synthesis has been implicated in the pathogenesis of excessive lung apoptosis and murine emphysema. Intracellular and paracellular-generated ceramides may trigger apoptosis and propagate the death signals to neighboring cells, respectively. In this study we
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