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주요 문서

810174P

Avanti

16:0-12:0 NBD PA

Avanti Research™ - A Croda Brand 810174P, powder

동의어(들):

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt)

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크기 선택

1 MG
₩406,914

₩406,914

예상 입고일2025년 4월 21일세부사항

벌크 견적 요청
모든 사진(2)

크기 선택

보기 변경
1 MG
₩406,914

About This Item

실험식(Hill 표기법):
C37H66N5O11P
CAS Number:
474942-96-6
Molecular Weight:
787.92
MDL number:
MFCD00467278
UNSPSC 코드:
12352211
NACRES:
NA.25

₩406,914

예상 입고일2025년 4월 21일세부사항

벌크 견적 요청

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (810174P-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand 810174P

배송 상태

dry ice

저장 온도

−20°C

일반 설명

Phosphatidic acid (PA) is a simple anionic cellular glycerophospholipid possessing a phosphomonoester polar head group and two long hydrophobic acyl chains.[1] 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PA is a fluorophore labeled phospholipid having 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.[2]

애플리케이션

16:0-12:0 NBD PA or 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable:
  • to incubate cells for the imaging of lyso phosphatidylcholine (PC) in P. falciparum live cells[3]
  • as a component of separation buffer for the separation of phosphoinositides and sphingolipids in the microchip devices[4]
  • in cytidine diphosphate diacylglycerol (CDP-DAG) synthase activity assay[5]

생화학적/생리학적 작용

Phosphatidic acid (PA) influences membrane fusion and membrane fission events[1] and membrane curvature.[6] It acts as a signaling molecule for various cellular processes including membrane trafficking and sperm hyper-activation.[7]

포장

5 mL Amber Glass Screw Cap Vial (810174P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Yasushi Tamura et al.
Cell metabolism, 17(5), 709-718 (2013-04-30)
CDP-diacylglycerol (CDP-DAG) is central to the phospholipid biosynthesis pathways in cells. A prevailing view is that only one CDP-DAG synthase named Cds1 is present in both the endoplasmic reticulum (ER) and mitochondrial inner membrane (IM) and mediates generation of CDP-DAG
Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Tamura Y, et al.
Cell Metabolism, 17(5), 709-718 (2013)
Priya Putta et al.
Biochimica et biophysica acta, 1858(11), 2709-2716 (2016-08-03)
Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid synthesis and numerous intracellular signaling cascades. The signaling function of PA is mediated by peripheral membrane proteins that specifically recognize PA. While numerous PA-binding proteins are known
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
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