800100C

18:1-2:0 DG

1-oleoyl-2-acetyl-sn-glycerol, chloroform

• 동의어(들): 1--(9Z-octadecenoyl)-2-acetoyl-sn-glycerol; DG(18:1(9Z)/2:0/0:0); OAG
• 실험식(Hill 표기법): C₂₃H₄₂O₅
• CAS Number: 86390-77-4
• Molecular Weight: 398.58
• MDL number: MFCD00166985
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: liquid
• 포장: pkg of 1 × 5 mL (800100C-10mg); pkg of 1 × 5 mL (800100C-25mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 800100C
• 농도: 2 mg/mL (800100C-10mg); 5 mg/mL (800100C-25mg)
• 지질 유형: neutral lipids; neutral glycerides
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: O([C@H](COC(=O)CCCCCCC\C=C/CCCCCCCC)CO)C(=O)C
• InChI: 1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1
• InChI key: PWTCCMJTPHCGMS-YRBAHSOBSA-N

설명

일반 설명

18:1-2:0 DG, also called 1-oleoyl-2-acetyl-sn-glycerol (OADG), is a synthetic analog of diacyl glycerol (DAG) and is membrane permeable.[1]

애플리케이션

18:1-2:0 DG (1-oleoyl-2-acetyl-sn-glycerol) has been used as a diacyl glycerol (DAG) analog to test its impact on DAG-sensitive channels in thalamocortical (TC) neurons.[2] It may be used as an internal standard for retention time calibration in ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS) for blood sample lipid quantification.[3] It may also be used as a protein kinase C (PKC) activator in adrenal glands.[4]

생화학적/생리학적 작용

1-oleoyl-2-acetyl-sn-glycerol (OAG) has ability to activate protein kinase C (PKC) .[4] It also inhibits TWIK-related acid-sensitive (TASK)-like potassium channels in peripheral arterial chemoreceptors.[2] OAG stimulates 5-lipooxygenase (5-LO) in human polymorphonuclear leukocytes (PMNL).[5] It also inhibits mitochondrial permeability transition pore (MPTP) formation and prevents fatty acid release and necrosis in lung fibroblasts.[6]

포장

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800100C-10mg)

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800100C-25mg)

저장 및 안정성

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

기타 정보

Delivery to cells: Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration: Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• 예방조치 성명서: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• 표적 기관: Central nervous system, Liver,Kidney
• WGK: WGK 3