추천 제품
설명
cholest-5-ene-3β,22(S)-diol-d7
분석
>99% (TLC)
양식
powder
포장
pkg of 1 × 1 mg (700051P-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand
배송 상태
dry ice
저장 온도
−20°C
일반 설명
22(S)-hydroxycholesterol is an enantiomer of 22(R)-hydroxycholesterol.[1] 22(S)-hydroxycholesterol-d7 is a deuterated form of 22(S)-hydroxycholesterol.
애플리케이션
22(S)-hydroxycholesterol-d7 may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma low-density lipoprotein (LDL).[2]
생화학적/생리학적 작용
22(S)-hydroxycholesterol (22(S)-HC) promotes glucose catabolism and uptake and is regarded as a potential target to treat type 2 diabetes.[3] 22(S)-HC also prevents the accumulation of lipids and lipid synthesis in hepatocytes and myotubes.[3] Unlike 22(R)-hydroxycholesterol, 22(S)-HC is not estrogenic and is not a ligand for liver X receptor (LXR).[1]
포장
5 mL Amber Glass Screw Cap Vial (700051P-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
가장 최신 버전 중 하나를 선택하세요:
Hiroyoshi Sato et al.
Bioscience, biotechnology, and biochemistry, 68(8), 1790-1793 (2004-08-24)
In order to test the estrogenic activity of sterol oxidation products from cholesterol and phytosterols, an estrogen-dependent gene expression assay was performed in estrogen receptor alpha-stably transformed HeLa cells. The ranking of the estrogenic potency of these compounds was different:
Nina Pettersen Hessvik et al.
The Journal of steroid biochemistry and molecular biology, 128(3-5), 154-164 (2011-11-05)
The aim of this study was to explore the effects of 22(S)-hydroxycholesterol (22(S)-HC) on lipid and glucose metabolism in human-derived cells from metabolic active tissues. Docking of T0901317 and 22(S)-HC showed that both substances fitted into the ligand binding domain
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