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700042P

Avanti

4β-hydroxycholesterol-d7

Avanti Research™ - A Croda Brand

동의어(들):

cholest-5-ene-3b,4b-diol(d7)

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크기 선택

1 MG
₩650,412

₩650,412

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모든 사진(2)

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보기 변경
1 MG
₩650,412

About This Item

실험식(Hill 표기법):
C27H39O2D7
CAS Number:
1246302-80-6
Molecular Weight:
409.70
MDL number:
MFCD15071187
UNSPSC 코드:
12352100
NACRES:
NA.25

₩650,412

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설명

cholest-5-ene-3,4-diol-d7

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (700042P-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O[C@@H]1[C@@H](C2=CC[C@H]3[C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)(CC[C@@H]3[C@]2(CC1)C)C)O

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D

InChI key

CZDKQKOAHAICSF-BZNWTYAPSA-N

일반 설명

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4).[1] 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

애플리케이션

4β-hydroxycholesterol-d7 has been used:
  • as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis[1]
  • to spike serum samples for mass spectrometry measurements[2]
  • as an internal standard for the quantification of human colon biopsies samples using HPLC-MS[3]

생화학적/생리학적 작용

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand.[3] The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.[3]

포장

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

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문서 라이브러리 방문

Owein Guillemot-Legris et al.
Journal of Crohn's & colitis, 13(2), 218-229 (2018-10-09)
Inflammatory bowel diseases [IBD] represent a challenging health issue with a complex aetiology involving genetic and environmental parameters. Although our understanding of the pathophysiology of IBD has improved, much remains to be explored. In this context, bioactive lipids, more specifically
Sarah J Woolsey et al.
Basic & clinical pharmacology & toxicology, 118(4), 284-291 (2015-09-25)
Due to high basal interindividual variation in cytochrome P450 3A (CYP3A) activity and susceptibility to drug interactions, there has been interest in the application of efficient probe drug phenotyping strategies, as well as endogenous biomarkers for assessment of in vivo
Mahmoud Hasan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1033-1034, 193-199 (2016-08-28)
Cytochrome P450 3A (CYP) enzymes are involved in the elimination of many drugs and are known to be regulated by several environmental factors. Thus, it was the aim of this study to develop and validate an analytical method allowing estimation

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