902683

BocNH-PEG5-acid

• 동의어(들): 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH₂COOH
• 실험식(Hill 표기법): C₁₇H₃₃NO₉
• CAS Number: 890152-41-7
• Molecular Weight: 395.45
• MDL number: MFCD31656900
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• 양식: liquid
• 반응 적합성: reaction type: Pegylations; reagent type: cross-linking reagent
• 작용기: Boc; amine; carboxylic acid
• 저장 온도: −20°C
• SMILES string: OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C17H33NO9/c1-17(2,3)27-16(21)18-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-14-15(19)20/h4-14H2,1-3H3,(H,18,21)(H,19,20)
• InChI key: OLLNIAGWMCSEJB-UHFFFAOYSA-N

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable