902578

Hydroxy-PEG6-t-butyl ester

≥95%

• 동의어(들): tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate, HO-PEG6-CO-OtBu
• 실험식(Hill 표기법): C₁₉H₃₈O₉
• CAS Number: 361189-64-2
• Molecular Weight: 410.50
• UNSPSC 코드: 51171641
• NACRES: NA.22

속성

• 분석: ≥95%
• 형태: liquid
• 반응 적합성: reagent type: cross-linking reagent
• refractive index: n/D 1.454
• density: 1.068
• 작용기: ester; hydroxyl
• 저장 온도: −20°C
• SMILES string: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
• InChI: 1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3
• InChI key: VGGDPFAYSOSIOK-UHFFFAOYSA-N

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

기타 정보

Synthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR

Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs: Synthesis and Antitumor Efficacy

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable