852686
6-Mercaptopurine-9-β-D-ribofuranoside
≥95.0% (HPLC)
동의어(들):
6-Mercaptopurine riboside, 6-Purinethiol riboside, 6-Thioinosine
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C10H12N4O4S
CAS Number:
Molecular Weight:
284.29
Beilstein:
40536
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
추천 제품
분석
≥95.0% (HPLC)
양식
powder
광학 활성
[α]/D −74±4°, c = 1% in 0.1 M NaOH
mp
220-223 °C (lit.)
저장 온도
−20°C
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(S)ncnc23
InChI
1S/C10H12N4O4S/c15-1-4-6(16)7(17)10(18-4)14-3-13-5-8(14)11-2-12-9(5)19/h2-4,6-7,10,15-17H,1H2,(H,11,12,19)/t4-,6-,7-,10-/m1/s1
InChI key
NKGPJODWTZCHGF-KQYNXXCUSA-N
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Lennard P L Gilissen et al.
Journal of Crohn's & colitis, 6(6), 698-707 (2012-03-09)
Therapeutic drug monitoring of active metabolites of thiopurines, azathioprine and 6-mercaptopurine, is relatively new. The proposed therapeutic threshold level of the active 6-thioguanine nucleotides (6-TGN) is ≥235 pmol/8×10(8) erythrocytes. The aim of this prospective cross-sectional study was to compare 6-TGN
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The Journal of thoracic and cardiovascular surgery, 144(1), 250-255 (2012-02-15)
To determine the role of the p-nitrobenzylthioinosine-sensitive equilibrative nucleoside transporter 1 (es-ENT1) in postmyocardial infarction reperfusion injury-mediated ventricular fibrillation and regional dysfunction. We used erythro-9 (2-hydroxy-3-nonyl)-adenine and p-nitrobenzylthioinosine to inhibit both adenosine deamination and transport in a canine model of
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Thiopurines (TP) represent an important therapeutic tool for the treatment of inflammatory bowel diseases (IBD) in the current situation of rising incidence and health care costs. The results of multiple clinical studies aimed at finding correlations between levels of TP
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