764825

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG M_n 2,000, PLGA M_n 4,500

• 동의어(들): PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
• Linear Formula: H[(C₃H₄O₂)_x(C₂H₂O₂)_y]_mO[C₂H₄O]_nCH₃
• UNSPSC 코드: 12162002
• NACRES: NA.23

속성

• 양식: pellets
• Quality Level: 100
• 피드(feed) 비율: lactide:glycolide 65:35
• 분자량: PEG M_n 2,000; PLGA M_n 4,500; average M_n 6,500 (total)
• 분해 기간: 1-4 weeks
• 전이 온도: T_m 241-246 °C
• PDI: ≤2.0
• 저장 온도: 2-8°C

설명

일반 설명

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.[1]

애플리케이션

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs. [2][3]

forming "stealth" pegylated microparticles

특징 및 장점

• Good biocompatibility, low immunogenicity and good degradability.
• Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.[1]

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable