764205

Alkyne-PEG4-maleimide

90% (HPLC)

• 동의어(들): Acetylene-PEG4-maleimide
• 실험식(Hill 표기법): C₁₈H₂₆N₂O₇
• Molecular Weight: 382.41
• MDL number: MFCD22380740
• UNSPSC 코드: 12352111
• PubChem Substance ID: 329767106
• NACRES: NA.22

속성

• 분석: 90% (HPLC)
• 양식: liquid
• 반응 적합성: reaction type: click chemistry; reagent type: cross-linking reagent
• mp: 62-67 °C
• 작용기: alkyne; maleimide
• 저장 온도: −20°C
• SMILES string: O=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O
• InChI: 1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21)
• InChI key: GHEBECZRHJXPTL-UHFFFAOYSA-N

설명

애플리케이션

Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.[1]

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable