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Merck
모든 사진(3)

주요 문서

760676

Sigma-Aldrich

Dibenzocyclooctyne-PEG4-maleimide

for Copper-free Click Chemistry

동의어(들):

Polyethylene glycol, DBCO-PEG4-maleimide

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크기 선택

1 MG
₩52,679
5 MG
₩250,502
50 MG
₩719,128

₩52,679


구입 가능 여부는 고객센터에 문의하십시오.

벌크 견적 요청

크기 선택

보기 변경
1 MG
₩52,679
5 MG
₩250,502
50 MG
₩719,128

About This Item

실험식(Hill 표기법):
C36H42N4O9
Molecular Weight:
674.74
MDL number:
UNSPSC 코드:
12161502
PubChem Substance ID:
NACRES:
NA.22

₩52,679


구입 가능 여부는 고객센터에 문의하십시오.

벌크 견적 요청

양식

solid

반응 적합성

reaction type: click chemistry
reagent type: cross-linking reagent

작용기

maleimide

저장 온도

−20°C

SMILES string

O=C(CCNC(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI

1S/C36H42N4O9/c41-32(14-18-39-34(43)11-12-35(39)44)38-17-20-47-22-24-49-26-25-48-23-21-46-19-15-33(42)37-16-13-36(45)40-27-30-7-2-1-5-28(30)9-10-29-6-3-4-8-31(29)40/h1-8,11-12H,13-27H2,(H,37,42)(H,38,41)

InChI key

VVFZXPZWVJMYPX-UHFFFAOYSA-N

애플리케이션

Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
Applications Include:
  • Protein-peptide conjugates
  • Antibody-enzyme or antibody-drug conjugates
  • Protein or peptide-oligonucleotide conjugates
  • Surface modification

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

Explore the principles and applications of click chemistry in drug discovery, highlighting efficient reactions that streamline the synthesis of bioactive compounds.

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