678635

1,2-Bis[(2R,5R)-2,5-dimethylphospholano]benzene monooxide

kanata purity

• 동의어(들): (2R,5R)-1-{2-[(2R,5R)-2,5-Dimethylphospholan-1-yl]phenyl}-2,5-dimethylphospholane 1-oxide, R,R-Me-BozPhos
• 실험식(Hill 표기법): C₁₈H₂₈OP₂
• CAS Number: 638132-66-8
• Molecular Weight: 322.36
• MDL number: MFCD09750450
• UNSPSC 코드: 12352005
• PubChem Substance ID: 24885440
• NACRES: NA.22

속성

• 양식: solid
• 광학 활성: [α]22/D -171°, c = 1 in chloroform
• mp: 116-122 °C
• 작용기: phosphine oxide; phosphine
• SMILES string: C[C@@H]1CC[C@@H](C)P1(C2=CC=CC=C2P3[C@H](C)CC[C@H]3C)=O
• InChI: 1S/C18H28OP2/c1-13-9-10-14(2)20(13)17-7-5-6-8-18(17)21(19)15(3)11-12-16(21)4/h5-8,13-16H,9-12H2,1-4H3/t13-,14-,15-,16-/m1/s1
• InChI key: ORZVYNTUPREFTI-KLHDSHLOSA-N

설명

일반 설명

1,2-Bis[(2R,5R)-2,5-dimethylphospholano]benzene monooxide is a chiral ligand whose copper complexes are used extensively in many organic reactions such as addition to imines, nitroalkenes, and reduction of β,β-disubstituted vinyl sulfones.[1][2][3][4][5]

애플리케이션

DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

1,2-Bis[(2R,5R)-2,5-dimethylphospholano]benzene monoxide can be used:

• As a ligand in the preparation of dihydroquinolones and dihydroisoquinolones through palladium-catalyzed C-H functionalization of cyclopropane derivatives.[2]
• As an organocatalyst in the [4+1] annulation reactions of 2-enoylpyridine pyridine N-oxides[3] and olefins[4] with Morita-Baylis-Hillman (MBH) carbonates to yield dihydrofurans derivatives enantioselectively.
• As a ligand in the copper-catalyzed synthesis of chiral nitroalkanes via the addition of dialkylzinc to β-nitroalkenes.[5]

법적 정보

Sold in collaboration with Kanata Chemical Technologies Inc. for research purposes only. These compounds were made and sold under license from E.I. du Pont de Nemours and Company, which license does not include the right to use the compounds in producing products for sale in the pharmaceutical field.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable