426016

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione

99%

• 실험식(Hill 표기법): C₈H₅F₃O₃
• CAS Number: 326-90-9
• Molecular Weight: 206.12
• EC Number: 206-315-1
• MDL number: MFCD00020935
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24866679
• NACRES: NA.22

속성

• Quality Level: 100
• 분석: 99%
• 양식: liquid
• refractive index: n20/D 1.528 (lit.)
• bp: 203 °C (lit.)
• mp: 19-21 °C (lit.)
• density: 1.391 g/mL at 25 °C (lit.)
• 작용기: fluoro; ketone
• 저장 온도: 2-8°C
• SMILES string: FC(F)(F)C(=O)CC(=O)c1ccco1
• InChI: 1S/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
• InChI key: OWLPCALGCHDBCN-UHFFFAOYSA-N

설명

일반 설명

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated.[1] Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria.[2] Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated.[3] The conformational analysis of the enol and keto form of FTFA has been reported.[4]

애플리케이션

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

• As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).[5]
• As reagent in the multistep synthesis of [¹³CD₂]benzylamine.[6]
• As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.[7]
• In the efficient syntheses of perfluoroalkyl substituted azoles.[8]
• Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.[9]

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): 188.6 °F - closed cup
• Flash Point (°C): 87 °C - closed cup
• 개인 보호 장비: Eyeshields, Gloves, type ABEK (EN14387) respirator filter