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Merck
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주요 문서

347795

Sigma-Aldrich

Sodium dichloroacetate

98%

동의어(들):

Dichloroacetic acid sodium salt

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크기 선택

10 G
₩133,777
50 G
₩329,063

₩133,777


출고 가능일2025년 4월 24일세부사항


벌크 견적 요청

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보기 변경
10 G
₩133,777
50 G
₩329,063

About This Item

Linear Formula:
Cl2CHCO2Na
CAS Number:
Molecular Weight:
150.92
EC Number:
MDL number:
UNSPSC 코드:
12352302
PubChem Substance ID:
NACRES:
NA.22

₩133,777


출고 가능일2025년 4월 24일세부사항


벌크 견적 요청

Quality Level

분석

98%

불순물

<2% ethyl alcohol

mp

198 °C (dec.) (lit.)

작용기

chloro

SMILES string

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChI key

LUPNKHXLFSSUGS-UHFFFAOYSA-M

유전자 정보

관련 카테고리

일반 설명

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.[1][2][3]

애플리케이션

Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.[4]

픽토그램

Health hazardExclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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시험 성적서(COA)

Lot/Batch Number

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

이미 열람한 고객

Preparing microporous carbon from solid organic salt precursors using in situ templating and a fixed-bed reactor.
Atkinson JD & Rood MJ.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 160, 174-181 (2012)
Mario Ammendola et al.
Scientific reports, 10(1), 6521-6521 (2020-04-18)
The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.
Pathak RK, et al.
ACS Chemical Biology, 9(5), 1178-1187 (2014)
Marie-Aline Neveu et al.
Oncotarget, 7(49), 81741-81749 (2017-01-14)
Reverting glycolytic metabolism is an attractive strategy for cancer therapy as upregulated glycolysis is a hallmark in various cancers. Dichloroacetate (DCA), long used to treat lactic acidosis in various pathologies, has emerged as a promising anti-cancer drug. By inhibiting the
Frank Comhaire
Medical hypotheses, 120, 65-67 (2018-09-18)
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably

문서

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

질문

1–6 / 6 질문  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 답변
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Is the product sterile and readily soluble in other solution for intravenous use in medical research?

    1 답변
    1. Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals. For research purposes, in animal models or in vitro assays, the prepared solution would require filter sterilization.

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  4. How can I make a solution of Product 347795, Sodium dichloroacetate?

    1 답변
    1. Sodium dichloroacetate is soluble in water at 50 mg/ml.

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  5. What is the Department of Transportation shipping information for this product?

    1 답변
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  6. I have heard that dichloroacetate has been used for cancer treatment.  Is Product 347795, Sodium dichloroacetate, the same chemical?

    1 답변
    1. Some research studies on the use of dichloroacetate as an anti-cancer agent have been performed.  At this time, no dichloroacetate compound or product has been approved for use as an anti-cancer drug.  The common salts of dichloroacetate are sodium and potassium, and these are what have been used in the research studies.  The Sigma-Aldrich products 347795, Sodium Dichloroacetate, and 348082, Potassium Dichloroacetate, are offered for laboratory use only, and are not manufactured or intended for human use.

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