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Merck
모든 사진(1)

Key Documents

218693

Sigma-Aldrich

1-Aminocyclohexanecarboxylic acid

98%

동의어(들):

Homocycloleucine

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About This Item

Linear Formula:
H2NC6H10CO2H
CAS Number:
Molecular Weight:
143.18
Beilstein:
2355692
EC Number:
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.22

분석

98%

형태

solid

반응 적합성

reaction type: solution phase peptide synthesis

mp

>300 °C (lit.)

응용 분야

peptide synthesis

SMILES string

NC1(CCCCC1)C(O)=O

InChI

1S/C7H13NO2/c8-7(6(9)10)4-2-1-3-5-7/h1-5,8H2,(H,9,10)

InChI key

WOXWUZCRWJWTRT-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

A Romanelli et al.
Journal of peptide science : an official publication of the European Peptide Society, 7(1), 15-26 (2001-03-14)
Secondary structure formation and stability are essential features in the knowledge of complex folding topology of biomolecules. To better understand the relationships between preferred conformations and functional properties of beta-homo-amino acids, the synthesis and conformational characterization by X-ray diffraction analysis
Wioleta Kowalczyk et al.
Journal of medicinal chemistry, 47(24), 6020-6024 (2004-11-13)
The synthesis and some pharmacological properties of two sets of analogues, one consisting of six peptides with 1-aminocyclohexane-1-carboxylic acid (Acc) in position 2 and the other with the amino acid in position 3, have been described. All the peptides were
Fernando Formaggio et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(1), 84-93 (2002-02-02)
The achiral, nitroxyl-containing alpha-amino acid TOAC (TOAC = 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid), in combination with the chiral alpha-amino acid C(alpha)-methyl valine [(alphaMe)Val], was used to prepare short peptides (from di- to hexa-) that induced the enantioselective oxidation of racemic 1-phenylethanol to acetophenone.
Mitsunobu Doi et al.
Biochemical and biophysical research communications, 297(1), 138-142 (2002-09-11)
Endomorphin (EM2, Tyr-Pro-Phe-Phe-NH(2)) can assume various conformations related to cis/trans-rotamers of the amide linkage of Tyr-Pro. To control isomerization, restricted or flexible components have been introduced at the Pro position. We focused on [Chx(2)]EM2, an EM2 analogue substituting 1-aminocyclohexane-1-carboxlylic acid
Olga Labudda-Dawidowska et al.
Journal of medicinal chemistry, 48(25), 8055-8059 (2005-12-13)
In the present work, a sterically constrained noncoded amino acid, 1-aminocyclohexane-1-carboxylic acid (Acc), was substituted in position 8 of the peptide chain of bradykinin (BK) and position 6, 7, or 8 of its B2 receptor antagonist [D-Arg0,Hyp3,Thi,(5,8)D-Phe7]BK, previously synthesized by

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