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Merck
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136115

Sigma-Aldrich

Thiocholesterol

동의어(들):

5-Cholestene-3β-thiol, Cholesteryl mercaptan

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1 G
₩600,170

₩600,170

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모든 사진(1)

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1 G
₩600,170

About This Item

실험식(Hill 표기법):
C27H46S
CAS Number:
1249-81-6
Molecular Weight:
402.72
EC Number:
215-003-4
MDL number:
MFCD00003647
UNSPSC 코드:
12352002
PubChem Substance ID:
24848256
NACRES:
NA.22

₩600,170

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양식

powder

광학 활성

[α]20/D −23°, c = 1 in chloroform

mp

97-99 °C (lit.)

저장 온도

2-8°C

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](S)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46S/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

QGVQZRDQPDLHHV-DPAQBDIFSA-N

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관련 카테고리

일반 설명

Thiocholesterol is a lipid similar to cholesterol except that the hydroxyl group is replaced with thiol group.[1]

애플리케이션

Thiocholesterol is used in biological cross-linking[2] and membrane[3] studies.
It can also be used as a chain transfer agent (CTA) for the radical polymerization of HPMA monolactate and HPMA dilactate monomers to form copolymers. [HPMA=N-(2-hydroxypropyl)methacrylamide][4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000263033
0000243850
0000263033
0000243850
0000177439

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Temperature-sensitive poly (N-(2-hydroxypropyl) methacrylamide mono/dilactate)-coated liposomes for triggered contents release
Paasonen L, et al
Bioconjugate Chemistry, 18(6), 2131-2136 (2007)
IRCS Med. Sci., 13, 68-68 (1985)
Avinash Bajaj et al.
Journal of medicinal chemistry, 51(8), 2533-2540 (2008-04-02)
A structure-activity investigation was undertaken to see the effect of the nature of the spacer on the gene transfection efficacies of thiocholesterol-derived cationic gemini lipids possessing disulfide linkage between the cationic headgroup and the thiocholesterol moiety. Three gemini cationic lipids
E A Dawidowicz et al.
Biochimica et biophysica acta, 644(2), 373-375 (1981-06-22)
Cholesterol is a major component of biological membranes, yet there is very little information concerning its distribution across the membrane. Recent experiments in our laboratory, using cholesterol oxidase, have demonstrated that cholesterol can undergo a rapid transbilayer movement in lecithin-cholesterol
G Zhou et al.
Biochimica et biophysica acta, 1258(2), 101-106 (1995-09-14)
Lecithin:cholesterol acyltransferase (LCAT) is a plasma enzyme which catalyses cholesteryl ester formation from lecithin and cholesterol present in the surface of plasma lipoproteins. Sterol fatty acid acceptors have previously been shown to require the presence of a trans conformation of
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질문

  1. For Thiocholesterol, what should I use to configure the solution since it looks like it should be hard to dissolve in water. Do you know how soluble it is in alcohol.

    1 답변

    1. A traditional solubility test is not performed on the material, but it is tested for optical activity and this is done as a 1% concentration in chloroform so, it would definitely be soluble in chloroform. It may also be slightly soluble in dichloromethane and methanol.

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