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M2922

Sigma-Aldrich

3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Synonym(s):

CL 218,872

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About This Item

Empirical Formula (Hill Notation):
C13H9F3N4
CAS Number:
66548-69-4
Molecular Weight:
278.23
MDL number:
MFCD00674912
UNSPSC Code:
12352200
PubChem Substance ID:
24278545

storage temp.

2-8°C

SMILES string

Cc1nnc2ccc(nn12)-c3cccc(c3)C(F)(F)F

Gene Information

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRG2(2566)

Biochem/physiol Actions

Selective agonist at the BZI benzodiazepine receptor.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J Karolak-Wojciechowska et al.
Bioorganic & medicinal chemistry, 2(8), 773-779 (1994-08-01)
Electronic parameters (molecular electrostatic potential MEP, charge distribution on the nitrogen atoms, dipole moment mu and ionization potential IP) were calculated by semiempirical quantum chemistry methods for 2 sets (X = H and m-CF3, the syn- and anti-rotamers of the
R K McNamara et al.
Epilepsy research, 16(1), 19-26 (1993-09-01)
To clarify the role of benzodiazepine receptors in kindling, the present experiment assessed the effects of CL 218,872 (1, 5, 10, and 20 mg/kg), a triazolopyridazine with a selective affinity for the putative benzodiazepine BZ1 receptor subtype, on the development
R L Hyson et al.
Journal of molecular neuroscience : MN, 8(3), 193-205 (1997-06-01)
Neurons in nucleus magnocellularis (NM) and nucleus laminaris (NL) of the chick brainstem auditory system show an unusual physiological response to GABA. Examination of these nuclei using in situ hybridization for GABAA receptor subunits showed a differential expression of the
D March et al.
European journal of pharmacology, 236(2), 333-336 (1993-05-19)
We have investigated the relative distributions of type I and type II benzodiazepine receptors in fetal, neonatal and adult human visual cortex using [3H]flunitrazepam and the triazolopyridazine, CL218872. Microdensitometry of autoradiograms show that while both benzodiazepine subtypes are found in
D Benke et al.
The Journal of biological chemistry, 269(43), 27100-27107 (1994-10-28)
Native gamma-aminobutyric acid type A (GABAA) receptors containing different beta-subunit variants were identified immunobiochemically with antisera recognizing selectively the beta 1-, beta 2-, or beta 3-subunit. As determined by immunoprecipitation, the beta 2-subunit was present in 55-60% of GABAA receptors
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