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  • Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt.

Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt.

Nature cell biology (2009-04-08)
Anna C-C Jang, Yu-Chiuan Chang, Jianwu Bai, Denise Montell
要旨

During development, elaborate patterns of cell differentiation and movement must occur in the correct locations and at the proper times. Developmental timing has been studied less than spatial pattern formation, and the mechanisms integrating the two are poorly understood. Border-cell migration in the Drosophila ovary occurs specifically at stage 9. Timing of the migration is regulated by the steroid hormone ecdysone, whereas spatial patterning of the migratory population requires localized activity of the JAK-STAT pathway. Ecdysone signalling is patterned spatially as well as temporally, although the mechanisms are not well understood. In stage 9 egg chambers, ecdysone signalling is highest in anterior follicle cells including the border cells. We identify the gene abrupt as a repressor of ecdysone signalling and border-cell migration. Abrupt protein is normally lost from border-cell nuclei during stage 9, in response to JAK-STAT activity. This contributes to the spatial pattern of the ecdysone response. Abrupt attenuates ecdysone signalling by means of a direct interaction with the basic helix-loop-helix (bHLH) domain of the P160 ecdysone receptor coactivator Taiman (Tai). Taken together, these findings provide a molecular mechanism by which spatial and temporal cues are integrated.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
エラスターゼ ブタ膵臓由来, Type III, lyophilized powder, Protein 55-85 %, ≥4.0 units/mg protein
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