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Merck
  • Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers.

Controlled release of liposome-encapsulated Naproxen from core-sheath electrospun nanofibers.

Carbohydrate polymers (2014-07-20)
Zhuang Li, Hongliang Kang, Ning Che, Zhijing Liu, Pingping Li, Weiwei Li, Chao Zhang, Chun Cao, Ruigang Liu, Yong Huang
要旨

Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials.

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製品内容

Sigma-Aldrich
コレステロール, Sigma Grade, ≥99%
Sigma-Aldrich
コレステロール, powder, BioReagent, suitable for cell culture, ≥99%
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SyntheChol® NS0サプリメント, 500 ×, synthetic cholesterol, animal component-free, aqueous solution, sterile-filtered, suitable for cell culture
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コレステロール 溶液, certified reference material, 10 mg/mL in chloroform
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コレステロール, from sheep wool, Controlled origin, meets USP/NF testing specifications
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ナプロキセン, meets USP testing specifications
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