Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.

Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.

Bioorganic & medicinal chemistry letters (2004-09-30)

Binoy Jose, Yusuke Oniki, Tamaki Kato, Norikazu Nishino, Yuko Sumida, Minoru Yoshida

要旨

Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors. Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents.

材料

製品番号

ブランド

製品内容

374059

Sigma-Aldrich

3-ブロモ-1,1,1-トリフルオロアセトン, 98%

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