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Merck
  • Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Macromolecular bioscience (2011-12-15)
Thimma R Thatiparti, Nicole Averell, Derek Overstreet, Horst A von Recum
要旨

A new strategy for affinity-based drug delivery by modification of the drug rather than modification of the device is presented. Rifampin is modified to contain either one or two PEG-adamantane arms, and the drug release properties of dimeric coumermycin are compared to novobiocin with only one biding domain. The drugs are loaded into affinity-based and diffusion-only delivery platforms, the loading efficiency is calculated, and the release kinetics is determined in vitro. The presence of additional binding domains prolongs the release of antibiotics. Release rates differ little between modified and unmodified drug from the diffusion-only system. The results demonstrate the feasibility of custom-tuning drug delivery by multiplexing interactions with an affinity-based polymer platform.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
ノボビオシン ナトリウム塩, ≥90% (HPLC)
カタログ番号
容量
在庫状況
単価
数量
Sigma-Aldrich
Novobiocin ナトリウム, meets USP testing specifications
現在、価格および在庫状況を閲覧できません。
Supelco
ノボビオシン ナトリウム塩, VETRANAL®, analytical standard
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カタログ番号容量在庫状況単価数量
250 mg
出荷予定日 2025年3月21日
¥13,300