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Merck
  • Oxiranyl anion-mediated synthesis of highly enantiomerically enriched styrene oxide derivatives.

Oxiranyl anion-mediated synthesis of highly enantiomerically enriched styrene oxide derivatives.

Organic letters (2002-07-06)
Vito Capriati, Saverio Florio, Renzo Luisi, Antonio Salomone
要旨

[reaction: see text] The stereospecific alpha-lithiation of optically active styrene oxides and the trapping reaction of the corresponding highly reactive intermediates with electrophiles to produce optically active styrene oxide derivatives are described. This methodology has been applied to the synthesis of an optically active oral antifungal agent of industrial interest.

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Sigma-Aldrich
水素化アルミニウムリチウム, powder, reagent grade, 95%
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水素化リチウムアルミニウム 溶液, 1.0 M in THF
Sigma-Aldrich
水素化リチウムアルミニウム 溶液, 2.0 M in THF
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水素化アルミニウムリチウム, pellets, reagent grade, 95%
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水素化リチウムアルミニウム 溶液, 1.0 M in diethyl ether
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水素化アルミニウムリチウム, hydrogen-storage grade
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水素化アルミニウムリチウム, ≥97.0% (gas-volumetric)
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水素化リチウムアルミニウム 溶液, 2.3 M in 2-methyltetrahydrofuran
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水素化リチウムアルミニウム 溶液, 0.5 M in 2-methoxyethyl ether
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水素化アルミニウムリチウム, ≥97.0% (gas-volumetric), tablet (5 g each)