W1520

WAY-200070

≥98% (HPLC)

• 別名: 7-ブロモ-2-(4-ヒドロキシフェニル)-1,3-ベンゾオキサゾール-5-オール, 7-ブロモ-2-(4-ヒドロキシフェニル)-5-ベンゾオキサゾロール
• 実験式（ヒル表記法）: C₁₃H₈BrNO₃
• CAS番号: 440122-66-7
• 分子量: 306.11
• NACRES: NA.77
• PubChem Substance ID: 329830426
• UNSPSC Code: 51111800
• MDL number: MFCD16618385
• Assay: ≥98% (HPLC)
• Form: solid

特性

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: ≥20 mg/mL
• originator: Wyeth
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2
• InChI: 1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H
• InChI key: BAAILVWEAXFTSF-UHFFFAOYSA-N

詳細

General description

WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Application

WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response.[1][2] WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.[3]

Biochem/physiol Actions

抗不安薬や抗うつ薬と同様の効果を有する強力かつ選択的なエストロゲン受容体-β(ER-β)アゴニスト(ER-αと比べた場合、IC₅₀ 2.3 nM対155 nM)。

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H319
• pcodes: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• 保管分類: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable