V7881

モノクロナール抗ビトロネクチン マウス宿主抗体

clone VIT-2, ascites fluid

• MDL番号: MFCD00162909
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: ascites fluid
• 抗体製品タイプ: primary antibodies
• クローン: VIT-2, monoclonal
• 分子量: antigen 65-75 kDa
• 含みます: 15 mM sodium azide
• 化学種の反応性: human
• テクニック: indirect ELISA: suitable; indirect immunofluorescence: suitable using human cultured fibroblasts; microarray: suitable; western blot: 1:2,500 using a denatured and reduced preparation of purified human plasma vitronectin
• アイソタイプ: IgM
• UniProtアクセッション番号: P04004
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... VTN(7448)

詳細

詳細

Monoclonal Anti-Vitronectin (mouse IgM isotype) is derived from the VIT-2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified human plasma vitronectin. Vitronectin is also referred as serum-spreading factor, S-protein of complement or epibolin. This monomeric acidic protein is one of the major multifunctional cell-adhesive glycoproteins in mammalian plasma and serum. This protein is usually seen as a mixture of 75 kDa and 65 kDa polypeptides. Human plasma and serum contain 0.1-0.4 mg/ml of vitronectin which is synthesized in the liver. It is also present in amniotic fluid and urine.

特異性

イムノブロッティングにおいて、フィブロネクチン、ラミニン、メロシン、IV型コラ-ゲン、A, B, C型コンドロイチン硫酸とは交差反応性を示しません。

免疫原

ヒト血漿ビトロネクチン

アプリケーション

Monoclonal Anti-Vitronectin antibody produced in mouse has been used in:

• immunocytochemisry
• western blotting
• immunoprecipitation
• immunofluorescence
• enzyme-linked immunosorbent assay (ELISA)

生物化学的／生理学的作用

Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b-9 complex. Vitronectin protects thrombin from inactivation by antithrombin III in the presence of heparin, binds and stabilizes the activity of plasminogen activator inhibitor and mediates many other physiological functions.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable