T5576

TMPH hydrochloride

solid, (Product is pure based on CHN, NMR and MS results)

• 別名: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate hydrochloride
• 実験式（ヒル表記法）: C₁₆H₃₂ClNO₂
• CAS番号: 849461-91-2
• 分子量: 305.88
• MDL番号: MFCD08277030
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724633
• NACRES: NA.77

特性

• 品質水準: 100
• 形状: solid
• 保管条件: under inert gas
• 色: white
• 溶解性: H₂O: 22 mg/mL at ~60 °C
• 保管温度: 2-8°C
• SMILES記法: Cl.CCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1
• InChI: 1S/C16H31NO2.ClH/c1-6-7-8-9-10-14(18)19-13-11-15(2,3)17-16(4,5)12-13;/h13,17H,6-12H2,1-5H3;1H
• InChI Key: XIDDVJIJIFWGIX-UHFFFAOYSA-N

詳細

アプリケーション

Studies using TMPH have reported that it can alleviate the seizure-causing effect of levamisole. Additionally, it has been reported that TMPH does not induce behavioral changes in mice¹.

生物化学的／生理学的作用

2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.

特徴および利点

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

調製ノート

TMPH hydrochloride is soluble in water at 22 mg/ml (at approx. 60° C).

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H317,H319,H335
• 注意書き: P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves