由来生物
human
リコンビナント
expressed in E. coli
アッセイ
≥90% (SDS-PAGE)
フォーム
liquid
分子量
~65 kDa (Human FTO aa 2-505 is fused at the N-terminus to a His-tag.)
包装
pkg of 10 μg
濃度
0.2 mg/mL
不純物
<1 EU/μg endotoxin (LAL test)
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... FTO(79068)
詳細
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
生物化学的／生理学的作用
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed.[3] The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome,[4] including higher fasting insulin, glucose, triglycerides, and lower high-density lipoprotein (HDL)-cholesterol. FTO stimulates adipogenesis, tumorigenesis, and drug resistance of cancer cells. It does so by reducing the levels of messenger RNA N6-methyladenosine (m6A) of certain genes post-transcription. The FTO single-nucleotide polymorphisms (SNPs) are associated with elevated body mass and obesity in humans.[5]
物理的形状
0.2 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.
保管分類コード
13 - Non Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP6526-10UG:
最新バージョンのいずれかを選択してください：
Xiaolan Deng et al.
Frontiers in endocrinology, 9, 396-396 (2018-08-15)
Fat mass and obesity-associated protein (FTO) single-nucleotide polymorphisms (SNPs) have been linked to increased body mass and obesity in humans by genome-wide association studies (GWAS) since 2007. Although some recent studies suggest that the obesity-related SNPs in FTO influence obesity
R Arlen Price et al.
BMC medical genetics, 9, 4-4 (2008-01-26)
FTO is a gene located in chromosome region 16q12.2. Recently two studies have found associations of several single nucleotide polymorphisms (SNPs) in FTO with body mass index (BMI) and obesity, particularly rs1421085, rs17817449, and rs9939609. We examined these three SNPs
Katherine A Fawcett et al.
Trends in genetics : TIG, 26(6), 266-274 (2010-04-13)
In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was identified in multiple populations, making FTO the first locus unequivocally associated with
Eikan Mishima et al.
PloS one, 10(11), e0143756-e0143756 (2015-11-26)
The biological roles of RNA modifications are still largely not understood. Thus, developing a method for detecting RNA modifications is important for further clarification. We developed a method for detecting RNA modifications called immuno-northern blotting (INB) analysis and herein introduce
Rachel M Freathy et al.
Diabetes, 57(5), 1419-1426 (2008-03-19)
Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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