SRP5346

CyclinC, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 別名: CCNC, CycC
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• リコンビナント: expressed in baculovirus infected Sf9 cells
• アッセイ: ≥70% (SDS-PAGE)
• フォーム: buffered aqueous glycerol solution
• 分子量: ~55 kDa
• NCBIアクセッション番号: NM_005190
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... CCNC(892)

詳細

詳細

Cyclin C is a member of the cyclin family of proteins. The gene encoding it is localized on human chromosome 6q16.2.[1]

生物化学的／生理学的作用

Cyclin C interacts with the cyclin-dependent kinase 8 (CDK8)[2] and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The mRNA levels of Cyclin C fluctuate during the cell cycle and peak at the G1 phase. Cyclin C acts as a critical regulator of the G0/G1 transition of human hematopoietic stem cells.[3] Cyclin C can also associate with CDK3 to enhance retinoblastoma phosphorylation at S807/811 during the G0/G1 transition,[4] and this phosphorylation is required for cells to exit G0 efficiently.

物理的形状

50 mM Tris-HCl溶液（pH 7.5、150 mM NaCl、10 mM グルタチオン、0.1 mM EDTA、0.25 mM DTT、0.1 mM PMSF、25％ グリセロール）

調製ノート

開封後は少量ずつに分注して－70℃で保管してください。操作を反復したり凍結融解を何度も繰り返したりしないでください。

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable