SRP4893

TFF1 ヒト

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 別名: BCEI, HP1, HPS, TFF-1, TFF1, pS2
• MDL番号: MFCD07370822
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥98% (HPLC); ≥98% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: ~8.2 kDa
• 包装: pkg of 20 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: endotoxin, tested
• NCBIアクセッション番号: P04155
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... TFF1(7031)

詳細

詳細

Trefoil factor 1(TFF1) is a member of trefoil factor family (TFF) and is encoded by the gene mapped to human chromosome 21q22.3.[1] Recombinant human TFF1 is an 8.2kDa polypeptide containing 60 amino acid residues. TFF1 consists of trefoil motif, which is a 40-amino acid domain with three conserved disulfides.[2] TFF1 is expressed and secreted by epithelial cells in the stomach or colon mucous membrane.[3]

生物化学的／生理学的作用

Trefoil factor family (TFF) members play a vital role in mucus stabilization and stimulation of normal epithelial cell restitution during wound healing via motogenic and antiapoptotic activities.[2] TFF1 prevents anoikis, chemicals or bad-induced apoptosis by decreasing the caspase-3, caspase-6, caspase-8, and caspase-9 activities.[1] TFF1 functions as a tumor suppressor in gastric cancer, whereas it acts as a tumor promoter in mucinous ovarian cancer via regulating the Wnt/β-catenin signaling pathway.[2] Elevated level of TFF1 is observed in patients suffering from Chronic kidney disease (CKD). TFF1 might function as a biomarker for early detection of CKD.[4]

物理的形状

凍結乾燥品(ろ過滅菌済み)。

再構成

バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.