SML3766

SRI-42127

≥98% (HPLC)

• 別名: 3-(1H-Indazol-6-yl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)imidazo[1,2-b]pyridazin-6-amine
• 実験式（ヒル表記法）: C₁₉H₂₀N₆O
• CAS番号: 2727872-68-4
• 分子量: 348.40
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (warmed)
• 保管温度: room temp

詳細

生物化学的／生理学的作用

Blood-brain barrier permeable HuR cytoplasmic dimerization inhibitor that reduces the stability of targeted mRNAs

SRI-42127 is a blood-brain barrier permeable imidazopyridazinamine analog that potently and reversibly inhibits the RNA-binding protein HuR multimerization and blocks HuR nucleocytoplasmic shuttling. SRI-42127 suppresses the expression and release of several pro-inflammatory mediators with minimal effect on anti-inflammatory cytokines. SRI 42127 weakens HuR interaction with Bcl-2 and Mcl-1 leading to induction of apoptosis and decreased tumor growth. SRI42127 subdues microglial activation in vivo and attenuates the recruitment/chemotaxis of neutrophils and monocytes.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable