SML3712

NG-497

≥98% (HPLC)

• 別名: 6-(4-Ethoxyphenyl)-4-methoxy-2-pyridinecarboxylic acid, 1-methylethyl ester, Isopropyl 6-(4-ethoxyphenyl)-4-methoxypicolinate, NG 497, NG497
• 実験式（ヒル表記法）: C₁₈H₂₁NO₄
• CAS番号: 2598242-66-9
• 分子量: 315.36
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C

詳細

生物化学的／生理学的作用

NG-497 is a non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor (IC50 = 1 μM, Ki = 0.5 μM) with little activity toward related human lipid hydrolases or ATGL orthologues from other species (<20% inhibition of mouse, rat, goat, pig, dog, marmoset ATGL at 50 μM). NG-497 abolishes hormone-induced lipolysis in human adipocytes (IC50 = 1.5 and 0.5 μM against 1 μM isoproterenol-induced total or hormonesensitive lipase (HSL)-independent FA release in Simpson-Golabi-Behmel syndrome adipocytes), but not in HepG2 that lacks ATGL hydrolase activity.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable