アッセイ
≥98% (HPLC)
フォーム
powder
光学活性
[α]/D -100 to -120°, c = 1 in dichloromethane
色
faint yellow to dark orange
溶解性
DMSO: 2 mg/mL, clear
保管温度
2-8°C
SMILES記法
Brc1c2c(c(c3c1CCN([C@H]3[C@H]4OC(=O)c5c4ccc(c5OC)OC)C)OC)OCO2
InChI
1S/C22H22BrNO7/c1-24-8-7-10-13(19(28-4)21-20(15(10)23)29-9-30-21)16(24)17-11-5-6-12(26-2)18(27-3)14(11)22(25)31-17/h5-6,16-17H,7-9H2,1-4H3/t16-,17+/m1/s1
InChI Key
PLMUFLAOTAHIIZ-SJORKVTESA-N
生物化学的／生理学的作用
Bromonoscapine is a microtubular disrupting agent that exhibits potent cytotoxic activity against breast, lung and other cancers.
microtubular disrupting agent
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML2620-25MG:
SML2620-BULK:
SML2620-VAR:
SML2620-5MG:
最新バージョンのいずれかを選択してください：
Akhilesh Kumar Verma et al.
Bioorganic & medicinal chemistry, 14(19), 6733-6736 (2006-06-21)
Three haloderivatives of noscapine 2-4 were synthesized chemoselectively and their in vitro cytotoxicity was assessed by MTT assay on U-87 human glioblastoma cell lines. At 50 microM concentration after 72 h, 9-chloronoscapine 2, 9-bromonoscapine 3 (EM011), and 9-iodonoscapine 4 killed
Jun Zhou et al.
Molecular pharmacology, 63(4), 799-807 (2003-03-20)
Noscapine, a microtubule-interfering agent, has been shown to arrest mitosis, to induce apoptosis, and to have potent antitumor activity. We report herein that two brominated derivatives of noscapine, 5-bromonoscapine (5-Br-nosc) and reduced 5-bromonoscapine (Rd 5-Br-nosc), have higher tubulin binding activity
Maged Henary et al.
Biochemical pharmacology, 92(2), 192-205 (2014-08-16)
Noscapine, an opium-derived 'kinder-gentler' microtubule-modulating drug is in Phase I/II clinical trials for cancer chemotherapy. However, its limited water solubility encumbers its development into an oral anticancer drug with clinical promise. Here we report the synthesis of 9 third-generation, water-soluble
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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