SML0999

ME0328

≥98% (HPLC)

• 別名: (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
• 実験式（ヒル表記法）: C₁₉H₁₉N₃O₂
• CAS番号: 1445251-22-8
• 分子量: 321.37
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: room temp
• SMILES記法: [nH]1c2c([c](nc1CCC(=O)N[C@@H](C)c3ccccc3)=O)cccc2
• InChI: 1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
• InChI Key: QIHBWVVVRYYYRO-ZDUSSCGKSA-N

詳細

生物化学的／生理学的作用

ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair.

ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair. ME0328 is the most potent isomer of the four ARTD3 ADP-ribosyltransferase inhibitors. ME0328 selectively inhibits ARTD3 (IC₅₀ of 890 nM) with weaker activity against ARTD1 and ARTD2 (IC₅₀ 6.3 and 10.8 μM, respectively), and no significant activity (IC₅₀ >30 μM) against any other ARTD enzyme. ME0328 appears to be the first selective inhibitor of ARTD3/PARP3.

特徴および利点

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable