SML0968

Y11

≥98% (HPLC)

• 別名: 1-(2-Hydroxyethyl)-3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide, NSC206142
• 実験式（ヒル表記法）: C₈H₁₇N₄O · Br
• CAS番号: 1086639-59-9
• 分子量: 265.15
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 25 mg/mL, clear
• 保管温度: −20°C

詳細

生物化学的／生理学的作用

Y11 inhibits the activity of focal adhesion kinase (FAK) by binding to the amino-terminal domain of FAK and blocking autophosphorylation of tyrosine residue Y397. Y11 inhibits the viability of SW620 and BT474 cancer cell lines and significantly reduces tumor volume in mouse xenografts.

Y11 has high cytotoxic effects with IC₅₀ values ranging from 3.87 to 4.66 mM, against non-small cell lung carcinoma (NSCLC) A549 cells. It plays a major role in the protein structures across the kunitz protein domain of viperids and elapids.

特徴および利点

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安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable