SML0794

T2AA hydrochloride

≥98% (HPLC)

• 別名: (S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol hydrochloride, T2-aminoalcohol hydrochloride
• 実験式（ヒル表記法）: C₁₅H₁₅I₂NO₃ · HCl
• CAS番号: 1380782-27-3
• 分子量: 547.55
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: Ic1c(c(cc(c1)C[C@H](N)CO)I)Oc2ccc(cc2)O
• InChI: 1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1
• InChI Key: NKOSKXJRVWVXRI-JTQLQIEISA-N

詳細

アプリケーション

T2AA hydrochloride has been used as a chemical inhibitor of proliferating cell nuclear antigen (PCNA) in vaccinia virus.

生物化学的／生理学的作用

T2AA is an inhibitor of PCNA/ PIP-Box interactions that binds to the PCNA cavity that interacts with PIP-Box sequences. Also T2AA inhibits PCNA Polδ3 interaction. T2AA inhibits de novo DNA synthesis, and in combination of cisplatin significantly increases growth inhibition in cancer cells. T2AA is a T3 analog that exhibits almost no thyroid hormone activity.

T2AA is an inhibitor of PCNA/ PIP-Box interactions; inhibits PCNA Polδ3 interaction.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable