SML0724

Bikaverin

from Fusarium subglutinans, ≥98% (HPLC)

• 別名: 6,11-Dihydroxy-3,8-dimethoxy-1-methylbenzo[b]xanthene-7,10, 12-trione, Lycopersin, NSC 215139
• 実験式（ヒル表記法）: C₂₀H₁₄O₈
• CAS番号: 33390-21-5
• 分子量: 382.32
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: Fusarium subglutinans
• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 溶解性: DMSO: 0.5 mg/mL (may require sonication and heating); chloroform: 0.5 mg/mL; dichloromethane: 0.5 mg/mL
• 保管温度: −20°C
• InChI: 1S/C20H14O8/c1-7-4-8(26-2)5-10-12(7)17(23)15-18(24)13-9(21)6-11(27-3)16(22)14(13)19(25)20(15)28-10/h4-6,24-25H,1-3H3
• InChI Key: ZOQMSOSJEWBMHP-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Bikaverin is a red pigment with a polyketide tetracyclic benzoxanthone structure. Bikaverin has an antibiotic activity against some protozoa and fungi and also inhibits Succinate- and NAD-linked respiration in rat mitochondria at 20 mg/mL. At higher concentrations (50 mg/mL) it acts as an oxidative phosphorylation uncoupling agent of tumor cells and isolated rat liver mitochondria. Bikaverin demonstrates antitumor activity on Erlich ascites carcinoma (EAC), leukemia and sarcoma cells.

再構成

Soluble in DMSO (0.5 mg/mL, may require sonication and heating). For further dilution, water based solutions can be used. Chloroform (0.5 mg/mL) and dichloromethane (0.5 mg/mL).

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P301 + P310
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable