SML0537

MI-1

≥98% (HPLC)

• 別名: 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-5,6,7,8-tetrahydro-[1]benzothieno[2,3-d]pyrimidine, CCG21397
• 実験式（ヒル表記法）: C₁₉H₂₅N₅S₂
• CAS番号: 433311-07-0
• 分子量: 387.57
• MDL番号: MFCD03268791
• UNSPSCコード: 12352202
• PubChem Substance ID: 329825540
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 15 mg/mL (clear solution, warmed)
• 保管温度: 2-8°C
• SMILES記法: CC1(C)CN=C(S1)N2CCN(CC2)c3ncnc4sc5CCCCc5c34
• InChI: 1S/C19H25N5S2/c1-19(2)11-20-18(26-19)24-9-7-23(8-10-24)16-15-13-5-3-4-6-14(13)25-17(15)22-12-21-16/h12H,3-11H2,1-2H3
• InChI Key: MNSXQGKLDTVOLP-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

MI-1 is a Menin-MLL interaction inhibitor. The mixed lineage leukemia (MLL) gene encodes MLL, a histone methyltransferase important in regulating gene transcription. MLL rearrangements and formation of fusion oncoproteins can block hematopoietic differentiation and increase proliferation, resulting in acute leukemias. Menin, encoded by the MEN1 gene, is a tumor suppressor associated with multiple endocrine neoplasia type 1. It also acts as an oncogenic co-factor of MLL fusion proteins. MI-1 inhibits Menin-MLL interaction with an IC₅₀ of 1.9 micromolar.

MI-1is a Menin-MLL interaction inhibitor.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable