おすすめの製品
アッセイ
≥98% (HPLC)
形状
powder
色
white to beige
溶解性
DMSO: 2 mg/mL (clear solution, warmed)
保管温度
room temp
SMILES記法
BrC1C(Br)C(Br)C(Br)C(Br)C1Br
InChI
1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChI Key
QFQZKISCBJKVHI-UHFFFAOYSA-N
生物化学的／生理学的作用
1,2,3,4,5,6-hexabromocyclohexane binds directly to a pocket within the kinase domain of JAK2 and inhibits autophosphorylation. The compound also blocks growth hormone induced JAK2 autophosphorylation without affecting EFGR autophosphorylation.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Eye Irrit. 2
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML0455-50MG:
SML0455-BULK:
SML0455-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Kotaro Horiguchi et al.
Cell and tissue research, 364(2), 395-404 (2015-11-18)
Secretion of hormones by the anterior pituitary gland can be stimulated or inhibited by paracrine factors that are produced during inflammatory reactions. The inflammation cytokine interferon-gamma (IFN-γ) is known to inhibit corticotropin-releasing factor (CRF)-stimulated adrenocorticotropin (ACTH) release but its signaling
Jeffrey D Kittilson et al.
Frontiers in endocrinology, 2, 30-30 (2011-01-01)
Previously, we found that the teleost fish, rainbow trout, possesses two growth hormone receptor (GHR) subtypes that display distinct ligand-binding and agonist-induced regulation features. In this study, we used Chinese hamster ovary-K1 cells stably transfected individually with the two trout
Anshu Agrawal et al.
Aging, 4(9), 648-659 (2012-10-16)
Advancing age leads to significant decline in immune functions. IL-21 is produced primarily by T follicular helper (Tfh) cells and is required for effective immune cell functions. Here we compared the induction of IL-21 in aged and young subjects. Our
Xue Jiang et al.
Frontiers in endocrinology, 11, 20-20 (2020-02-23)
In mammals, local production of tumor necrosis factor α (TNFα) inhibits growth hormone (GH)-induced IGF-I expression at tissue level and contributes to GH resistance caused by sepsis/endotoxemia and inflammation. Although the loss of GH responsiveness can be mediated by a
Shirley C Mills et al.
Cellular signalling, 28(4), 316-324 (2016-01-26)
Chemotaxis or directed cell migration is mediated by signalling events initiated by binding of chemokines to their cognate receptors and the activation of a complex signalling cascade. The molecular signalling pathways involved in cell migration are important to understand cancer
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