SML0389

PF-514273

≥98% (HPLC)

• 別名: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
• 実験式（ヒル表記法）: C₂₁H₁₇Cl₂F₂N₃O₂
• CAS番号: 851728-60-4
• 分子量: 452.28
• MDL番号: MFCD12032112
• UNSPSCコード: 12352202
• PubChem Substance ID: 329825387
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: >5 mg/mL (warmed)
• 保管温度: −20°C
• SMILES記法: CC(F)(F)CN1CCOc2c(nn(-c3ccccc3Cl)c2-c4ccc(Cl)cc4)C1=O
• InChI: 1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3
• InChI Key: FJMQJSUOOGOWBD-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

PF-514273 is a highly selective CB1 antagonist. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. PF-514273 inhibits food intake and weight gain in rodents.

特徴および利点

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable